Promising disease product candidates for difficult to treat diseases

Website Pipeline2022.JPG

ANV221 - Targeting the Cancer Glycobiome 
(Not yet FDA/EU approved - for clinical awareness, research, and investor purposes only)

A novel drug candidate that was superior to approved standard of care drugs in reducing tumor size and suppressing metastasis in mouse models.  

“…(Aberrant) glycosylation enables acquisition of all 10 currently accepted hallmarks of cancer” – Institute of Genetic Medicine (2016)*

Several solid tumor cancers have been found to upregulate N-glycosylation to fuel one or more of their hallmark behaviors.  ANV221 is a novel drug candidate that interrupts this cycle in vivo models leading to:   

  • Disruption of chronic proliferation signaling

  • Activation of evolutionary conserved apoptosis (cell suicide) pathways

  • Suppressing cell invasiveness, migration and metastasis

  • Reversing stem like transformations, thus enhancing tumor vulnerability to other cytotoxic therapies

  • Low observed toxicity

ANV221 was awarded Orphan Drug Designation for the treatment of Pancreatic Cancer by the FDA. 

"PDAC xenograft tumors were disappeared in two weeks."
- Michio Kurosu, PhD University of Tennessee Health Science Center 

*Oncotarget. 2016; 7:35478-35489. https://doi.org/10.18632/oncotarget.8155